Dissident AIDS Database

Antibody testsSeroconversion after immuno-deficiencyRisk groupHomosexuals
Estimation of time since infection using longitudinal disease-marker data.
 Dubin N, Berman S, Marmor M, Tindall B, Des Jarlais D, Kim M.
  "We propose a method to estimate the usually unknown time since infection for individuals infected with human immunodeficiency virus type 1 (HIV-1)... We applied the method to prevalent cohort data both from intravenous drug users and from homosexual/bisexual men... For the homosexual/bisexual men the estimated mean time since infection was 16.7 months from infection at a presumed mean CD4 level of 699 cells/ml to first positive antibody test at an average CD4 level of 577 cells/ml. We performed a validation study using initially seronegative subjects in these cohorts who seroconverted to HIV-1-positive antibody status during the follow-up period... In the cohort of homosexual/bisexual men, however, there was a total of 70 seroconverters with relevant data..."
  Stat Med 1994 Feb 15;13(3):231-441994
Patterns of T lymphocyte changes with human immunodeficiency virus infection: from seroconversion to the development of AIDS.
 Lang W, Perkins H, Anderson RE, Royce R, Jewell N, Winkelstein W, Jr.
  Prospective studies have demonstrated that the T-cells of male homosexuals using psychoactive drugs and sexual stimulants may decline prior to infection with HIV. For example, the T-cells of 37 homosexual men from San Francisco declined steadily prior to HIV infection for 1.5 years from over 1200 to below 800 per Ál. Some even had fewer than 500 T-cells 1.5 years before seroconversion. Although recreational drug use was not mentioned in these articles, other studies of the same cohort of homosexual men from San Francisco described extensive use of recreational drugs including nitrites
  JAIDS 1989; 2: 63-69.1989
Clinical, Immunologic, and Serologic Findings in Men at Risk for Acquired Immunodeficiency Syndrome.
 Lang W, Anderson RE, Perkins H, Grant RM, Lyman D, Winkelstein W, Royce R, Levy JA.
  Prospective studies have demonstrated that the T-cells of male homosexuals using psychoactive drugs and sexual stimulants may decline prior to infection with HIV. For example, the T-cells of 37 homosexual men from San Francisco declined steadily prior to HIV infection for 1.5 years from over 1200 to below 800 per Ál. Some even had fewer than 500 T-cells 1.5 years before seroconversion. Although recreational drug use was not mentioned in these articles, other studies of the same cohort of homosexual men from San Francisco described extensive use of recreational drugs including nitrites
  JAMA 1987; 257: 326-330.1987
Evidence that prior immune dysfunction predisposes to human immunodeficiency virus infection in homosexual men.
 Marion SA, Schechter MT, Weaver MS, McLeod WA, Boyko WJ, Willoughby B, Douglas B, Craib KJP, O'Shaughnessy M.
  33 HIV-free male homosexuals from Vancouver, Canada, had "acquired" immunodeficiency prior to HIV infection. Again this study did not mention drug use, but in other articles the authors reported that all men of this cohort had used nitrites, cocaine and amphetamines.
  JAIDS 1989; 2: 178-1861989
The Drug-AIDS Hypothesis
 Duesberg Peter, Rasnick David
  The MAC study reported that about 450 (16% of 2795) HIV-free, homosexual American men from Chicago, Baltimore, Pittsburgh and Los Angeles had acquired immunodeficiency, having less than 600 T-cells per Ál, prior to HIV infection (Kaslow RA, Blackwelder WC, Ostrow DG, Yerg D, Palenicek J, Coulson AH, Valdiserri RO. No evidence for a role of alcohol or other psychoactive drugs in accelerating immunodeficiency in HIV-1-positive individuals. J Am Med Assoc 1989; 261: 3424-3429). Many HIV-positive and -negative men of this cohort had essentially the same degree of lymphadenopathy: "Although seropositive men had a significantly higher mean number of involved lymphnode groups than seronegative men (5.7 compared to 4.5 nodes, p<0.005), the numerical difference in the means is not striking" (Kaslow RA, Phair JP, Freidman HB, Lyter RE, Solomon RE, Dudley J, Polk F, Blackwelder W. Infection with the Human Immunodeficiency Virus: clinical manifestations and their relationship to immunodeficiency. Ann Intern Med 1987; 107: 474-480). 83% had used one drug, and 60% had used two or more drugs during sex in the previous six months (Ostrow DG, Van Raden MJ, Fox R, Kingsley LA, Dudley J, Kaslow RA, the Multicenter AIDS Cohort Study (MACS). Recreational drug use and sexual behavior change in a cohort of homosexual men. AIDS 1990; 4: 759-765).
  Continuum Feb./March 19971997