Dissident AIDS Database

Antibody testsUnreliabilityFalse positiveAnimals
Studies with canine sera that contain antibodies which recognize human immunodeficiency virus structural proteins.
 Strandstrom HV et al.
  “144 dog sera were tested on Chiron Western blot strips. Of these, 72 sera (50%) reacted with one or more HIV recombinant proteins”
  Cancer Res. 1990 Sep 1;50(17 Suppl):5628-5630.1990
Binding of glycoprotein 120 and peptides from the HIV-1 envelope by autoantibodies in mice with experimentally induced systemic lupus erythematosus and in patients with the disease.
 Bermas BL, Petri M, Berzofsky JA, Waisman A, Shearer GM, Mozes E.
  Systemic lupus erythematosus (SLE) and infection with the human immunodeficiency virus type 1 (HIV) are diseases that are characterized by immune dysregulation and autoantibody production. In this article we identify and characterize IgG antibodies from mice with SLE and SLE patients that bind HIV gp120 and HIV envelope-derived peptides... We tested sera from various strains of mice in which experimental SLE was induced by immunization with a human monoclonal anti-DNA antibody that bears a common idiotype, as well as from 93 patients with SLE and 31 controls (17 healthy controls, 14 patients with other autoimmune diseases) for the presence of antibodies reactive to gp120 by an ELISA... Forty-three percent of SLE patients made antibodies that bound to gp120 at titers greater than 1:40, whereas 12% of healthy control sera (p < or = 0.02) and 14% of patients with other autoimmune diseases contained such antibodies (p < or = 0.05)... In both mice and SLE patients, sera reactive with gp120 recognized the same three envelope peptides...
  AIDS Res Hum Retroviruses. 1994 Sep;10(9):1071-7.1994
Anti-HIV and anti-anti-MHC antibodies in alloimmune and autoimmune mice.
 Kion TA, Hoffmann GW.
  [Healthy mice injected with lymphocytes of similar mice] “Alloimmune mice...were shown to make antibodies against gp120 and p24 of human immunodeficiency virus (HIV), and mice of [two] autoimmune strains...made antibodies against gp120. This is surprising because the mice were not exposed to HIV. [i.e. HIV proteins are found in uninfected mice!!]”
  Science. 1991 Sep 6;253:1138-40.1991