Dissident AIDS Database

Antibody testsUnreliabilityFalse positiveBlood transfusion
Serologic testing for human immunodeficiency virus antibodies.
 Steckelberg JM, Cockerill F.
  "One notable association with false positive ELISA reactivity in some commercial preparations has been patients with anti-HLA-DR4 antibodies, most often … multiply transfused patients
  Mayo Clin Proc. 1988;63:373-9.1988
HIV/AIDS Surveillance Report
 US Centers for Disease Control & Los Angeles County Department of Health Services
  “41 adults/adolescents and 2 children developed AIDS after receiving blood screened negative for HIV antibody. 13 additional adults developed AIDS after receiving tissue, organs, or artificial insemination from HIV-infected donors. Four of the 13 received tissue, organs, or artificial insemination from a donor who was negative for HIV antibody at the time of donation. ”
  U.S. HIV and AIDS cases reported through December 2001. CDC. 2002;13(2).2002
Transmission of AIDS from blood screened negative for antibody to the human immunodeficiency virus.
 Conley LJ, Holmberg SD.
  “158 patients with AIDS…had purportedly acquired their infections from blood that was negative on screening for HIV [in the US after March, 1985]…Of the 97 patients with completed follow-up…9 had received blood from donors later found to be negative for HIV antibody [but had no other risk factor for HIV infection]”
  N Engl J Med. 1992 May 28;326(22):1499-500.1992
Transmission of human immunodeficiency virus (HIV) by blood transfusion screened as negative for HIV antibody.
 Ward JW et al.
  “The remaining 5 recipients reported no risk factors for HIV infection other than transfusion, but the donors to 4 of these were retested and found to be negative for HIV antibody 10 months or more after donation.”
  N Engl J Med. 1988 Feb 25;318(8):473-7.1988
Competitive ELISA for the detection of HTLV-III antibodies.
 Saxinger WC, Gallo RC.
  “Three chimpanzees were inoculated with AIDS plasma [i.e. plasma from someone with AIDS, not purified virus] and one was inoculated only with normal human plasma. Blood was sampled biweekly from each animal and serum was tested in the standard indirect ELISA for HTLV-III [HIV] antibodies...all four of the animals were positive for passively transferred HTLV-III”
  US Patent Office. 1987 Apr 28;4,661,445.1987
Laboratory diagnosis of human immunodeficiency virus infection.
 Proffitt MR, Yen-Lieberman B.
  "Notable causes of false-positive reactions have been anti-HLA-DR antibodies that sometimes occur in … multiply transfused patients.
  Inf Dis Clin North Am. 1993;7:203-19.1993