Dissident AIDS Database

Antibody testsUnreliabilityFalse positiveHemophilia/Factor VIII
Coincidental appearance of LAV/HTLV-III antibodies in hemophiliacs and the onset of the AIDS epidemic
 Evatt, B.L., Gomperts, E.D., McDougal, J.S. & Ramsey, R.B.
  "It is possible that antibody to LAV is acquired passively from immunoglobulins found in factor VIII concentrates..... Likewise, it is possible that seropositivity is caused not by infectious virus but by immunisation with noninfectious LAV or LAV proteins derived from virus disrupted during the processing of plasma into factor VIII concentrate"
  NEJM 312, 483-486 (1985).1985
HIV transmission to patients with hemophilia by heat-treated, donor-screened factor concentrate.
 Remis, R. S., O'Shaughnessy, M. V., Tsoukas, C., Growe, G. H., Schechter, M. T., Palmer, R. W. H. & Lawrence, D. N.,
  "HIV" has been "isolated" from children with haemophilia who had no other risk factors other than haemophilia, where each plasma unit from which factor VIII was made "had been tested for HIV antibody, hepatitis B surface antigen and alanine aminotransferase, usually within 2 days after collection" and where the source plasmas from which the lots of factor VIII were made were retested "within several months after donating factor VIII, and were found negative"
  Can. Med. Assoc. J. 1990. 1247-1254.1990
Inactivation of HIV-1 and HIV-2 by various manufacturing procedures for human plasma proteins.
 Hilfenhaus, J. W., Gregersen, J. P., Mehdi, S. & Volk, R.,
  "HIV" has been "isolated" from children with haemophilia who had no other risk factors other than haemophilia and where factor VIII was heat treated at 60=F8C for 30 hours (according to some authors HIV is "completely inactivated in the samples within a few minutes", of heating
  Cancer Detect. Prev. 1990. 14:369-375.1990
Laboratory evidence of active HIV-1 infection in Canadians with hemophilia associated with administration of heat-treated factor VIII.
 Neumann, P., O'Shaughnessy, M., Remis, R., Tsoukas, C., Lepine, D. & Davis, M.,
  "HIV" has been "isolated" from children with haemophilia who had no other risk factors other than haemophilia and where the source plasmas from which the lots of factor VIII were made were retested "within several months after donating factor VIII, and were found negative"
  J. Acquir. Immune Defic. Syndr. 1990. 3:278-281.1990
The prevalence and interaction of human immunodeficiency virus and hepatitis B infections in Israeli hemophiliacs.
 Brenner, B., Schwartz, S., Ben-Porath, E., Tatarsky, I., Varon, D. & Martinowitz, U.,
  haemophilia patients have hypergammaglobulinaemia and hypergammaglobulinaemia correlates with HIV seropositivity
  Isr. J. Med. Sci. 1991. 27:557-561.1991
Clin. Exp. Immunol. 1989. 75:178-183.
 Daniel, V., Schimpf, K. & Opelz, G.,
  haemophilia patients have anti-lymphocyte antibodies
  Lymphocyte autoantibodies and alloantibodies in HIV-positive haemophilia patients.1989
High prevalence of anti-cardiolipin antibody, C1q-, C3d- and mRF-IgG immune complexes, and anti-nuclear antibody in hemophiliacs irrespective of infection with human immunodeficiency virus type 1.
 Matsuda, J., Gohchi, K., Tsukamoto, M., Saitoh, N. & Kinoshita, T.
  in one study, 12% of haemophiliacs were found to have HTLV-I antibody, (the molecular weights of HTLV-I and HIV-1 proteins are the same), 74% anti-cardiolipin antibodies, 28% anti-nuclear antibodies and 85% immune complexes
  J. Acquir. Immune Defic. Syndr. 1993. 6:1120-1124.1993
Seroconversion to HTLV-III in haemophiliac given heat-treated factor VIII concentrate.
 Van den Berg, W., Ten Cate, J. W., Breederveld, C. & Goudsmit, J.,
  Haemophiliacs who received only heat treated factor VIII also became HIV seropositive
  Lancet I:803-804. 1986.1986
Haemophiliacs with HIV seroconversion associated with heat-treated products: are they actively infected?
 Damjanovic, V.,
  The finding that haemophiliacs who received only heat treated factor VIII also became HIV seropositive, was interpreted as evidence that these patients "may not have been infected but rather immunized by preserved viral proteins"
  JAMA 261:1275. 1989.1989
Haemophiliacs with HIV seroconversion associated with heat-treated products: are they actively infected? (Reply).
 Jackson, J. B.,
  The finding that haemophiliacs who received only heat treated factor VIII also became HIV seropositive, was interpreted as evidence that these patients "may not have been infected but rather immunized by preserved viral proteins"
  JAMA 261:1275. 1989.1989