Dissident AIDS Database

Antibody testsUnreliabilityLack of gold standardGeneral
Retroviruses. in Viral infections of humans
 Blattner, W. A.
  "One difficulty in assessing the specificity and sensitivity of retrovirus assays is the absence of a final 'gold standard'. In the absence of gold standards for both HTLV-I and HIV-1, the true sensitivity and specificity for the detection of viral antibodies remain imprecise".
  Plenum Medical Book Company: New York, 1989, 3rd Edition, ed Evans, A.S. pp. 545-592.1989
AIDS in Africa: distinguishing fact and fiction
 Papadopulos-Eleopulos E, Turner Valendar F, Papadimitriou John M, Bialy Harvey
  "For some unknown reason, HIV experts [such as Mulder and Burke] determine the specificity of the HIV antibody tests by repeating an antibody test or a combination of antibody tests an arbitrary number of times and use another antibody test as a gold standard... an outcome which could eventuate by making the same mistake twice...Although Mortimer et al. as well as Gallo and his colleagues used clinical and/or epidemiological features to determine the specificity of the HIV antibody tests, this in scientifically invalid."
  World Journal of Microbiology & Biotechnology (1995) 11, 135-1431995
Screening for HIV: can we afford the false positive rate?.
 Meyer KB, Pauker SG.
  “The meaning of positive tests will depend on the joint [ELISA/WB] false positive rate. Because we lack a gold standard, we do not know what that rate is now. We cannot know what it will be in a large-scale screening program”
  NEJM. 1987;317(4):238-41.1987