Dissident AIDS Database
|Antibody tests||Unreliability||Lack of gold standard||General|
|Retroviruses. in Viral infections of humans|| ||Blattner, W. A.
| ||"One difficulty in assessing the specificity and sensitivity of retrovirus assays is the absence of a final 'gold standard'. In the absence of gold standards for both HTLV-I and HIV-1, the true sensitivity and specificity for the detection of viral antibodies remain imprecise".|
| ||Plenum Medical Book Company: New York, 1989, 3rd Edition, ed Evans, A.S. pp. 545-592.||1989|
|AIDS in Africa: distinguishing fact and fiction|| ||Papadopulos-Eleopulos E, Turner Valendar F, Papadimitriou John M, Bialy Harvey
| ||"For some unknown reason, HIV experts [such as Mulder and Burke] determine the specificity of the HIV antibody tests by repeating an antibody test or a combination of antibody tests an arbitrary number of times and use another antibody test as a gold standard... an outcome which could eventuate by making the same mistake twice...Although Mortimer et al. as well as Gallo and his colleagues used clinical and/or epidemiological features to determine the specificity of the HIV antibody tests, this in scientifically invalid."|
| ||World Journal of Microbiology & Biotechnology (1995) 11, 135-143||1995|
|Screening for HIV: can we afford the false positive rate?.|| ||Meyer KB, Pauker SG.
| ||“The meaning of positive tests will depend on the joint [ELISA/WB] false positive rate. Because we lack a gold standard, we do not know what that rate is now. We cannot know what it will be in a large-scale screening program”|
| ||NEJM. 1987;317(4):238-41.||1987|