Dissident AIDS Database

CD4+ countsInconsistent surrogate markerCorrelation with healthLow CD4+ without immunodeficiency
Non-HIV AIDS: nature and strategies for its management.
 Bird AG.
  “The CDC definition of idiopathic CD4 lymphocytopenia [HIV-free AIDS] does not include any clinical parameters. [One group] comprises a series of individuals...[Some of these are] individuals whose CD4 counts are below the lower end of the normal range and who have constitutionally low CD4 blood levels consistently over a period of time without ill effect...their low CD4 counts may have no prognostic significance”
  Journal of Antimicrobial Chemotherapy. 1996;37(B):171-183.1996
State-of-the-Art Panel on Anti-Retroviral Therapy for Adult HIV-Infected Patients. Anti-retroviral therapy for adult HIV-infected patients. Recommendations from a state-of-the-art conference.
 National Institute of Allergy and Infectious Diseases
  “The CD4+ cell counts vary from day to day and laboratory to laboratory, and similar levels do not necessarily reflect the same disease status in all patients. For example, very low CD4+ cell counts (less than 0.05x10**9/L (50/microL)) usually indicate advanced disease; however, some patients with these levels remain asymptomatic for extended periods of time while others succumb rapidly”
  JAMA. 1993;270:2583-9.1993
Mysteries of HIV: challenges for therapy and prevention.
 Levy JA.
  “Some healthy seropositive individuals lose a large proportion of their CD4+ lymphocytes, yet do not develop symptoms...Two patients followed at our medical center have had only 5% of their normal CD4+ cell number for over a year without any new symptoms. Thus, predictions on the development of opportunistic infections or cancers based solely on a decrease in CD4+ cells could be misleading.”
  Nature. 1988 Jun 9;333:519-22.1988
Long-term survival without clinical AIDS after CD4+ cell counts fall below 200
 Hoover, Donald R. et al.
  "Of the 446 men in the MACS study with 200 T-cells, 26% (118) were free of AIDS illnesses three years later.“
  AIDS, 9:145 (1995)1995