Dissident AIDS Database

Co-factorsAntibioticsBactrimLymphocytopenia
Rapid disease progression in human immunodeficiency virus type 1-infected individuals with adverse reactions to trimethoprim-sulfamethoxazole prophylaxis.
 Veenstra J et al.
  “Adverse reactions to TMP-SMZ were associated with a more rapid progression to AIDS and death and with a more rapid decline in CD4+ cell counts...”
  Clin Infect Dis. 1997 May;24(5):936-41.1997
Discontinuation of chemoprophylaxis against Pneumocystis carinii pneumonia in patients with HIV infection.
 Yangco BG, Von Bargen JC, Moorman AC, Holmberg SD
  "To compare PCP incidence in HIV-infected patients who had sustained CD4+ lymphocyte counts greater than 200 cells/mm3 and who either discontinued or continued PCP prophylaxis. Nonrandomized prospective cohort study. 146 patients had follow-up visits for for a mean of 18.2 months after discontinuation of PCP prophylaxis, and 345 patients who continued PCP prophylaxis had follow-up visits for a mean of 14.0 months. Patients who discontinued PCP prophylaxis had higher maximum and minimum CD4+ cell counts and lower viral loads than patients who continued PCP prophylaxis. Discontinuation of PCP chemoprophylaxis may be appropriate for some HIV-infected ambulatory patients."
  Ann Intern Med 2000 Feb 1;132(3):201-52000
Anemia, Neutropenia, and Thrombocytopenia: Pathogenesis and Evolving Treatment Options in HIV-Infected Patients.
 Levine AM
  “Myelosuppression [deficiency of white blood cell production] and neutropenia [deficiency of one type of white blood cells responsible for clearing bacteria and cellular debris] may result from any one of several medications commonly used in HIV-infected patients [including anti-PCP therapies Trimethoprim, Pyrimethamine and Pentamidine]”
  Medscape. 2001 May 23.2001