|Aneuploid Induction by Benzo[a]Pyrene and Polyploid Induction by 7,12-Dimetylbenz[a]Antracene in Chinese Hamster Cells V79-MZ and V79.|| ||MATSUOKA A, OZAKI M, TAKESHITA K, et al.
| ||Rats and mice treated with AZT for 7 weeks developed anemia, neutropenia, lymphopenia, thrombocytopenia, bone marrow depletion and weight loss|
| ||Mutagenesis 1997; 12:365-372.||1997|
|The chemical bases of the various AIDS epidemics: recreational drugs, anti-viral chemotherapy and malnutrition|| ||DUESBERG PETER, KOEHNLEIN CLAUS, RASNICK DAVID
| ||The high doses of protease inhibitors currently administered to patients are at minimum 50 times that needed to completely inhibit the cellular, intestinal aspartyl protease cathepsin D (calculation based on the Roche inhibitor Saquinavir; the Abbott inhibitor Ritonivar is 1000 times more potent against cathepsin D than Saquinavir), (Deeks S G, Smith M, Holodniy M and Kahn J O 1997 HIV-1 protease inhibitors. A review for clinicians; Jama 277 145– 153). Mice in which cathepsin D is deleted develop anorexia, their “Thymus and spleen undergo massive destruction with fulminant loss of T and B cells”, and die about 26 days after birth (Saftig P et al 1995 Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells; EMBO J. 14 3599–3608). Thus protease inhibitors can cause at least three AIDS defining diseases, anorexia (weight loss), T-cell deficiency and death. In addition, diarrhea – which is also AIDS defining disease is a common problem with all the protease inhibitors.|
| ||J. Biosc, Vol. 28 No. 4, June 2003, 383–412||2003|
|Genetic Imprecision.|| ||LEWIS R.
| ||In a similar experiment, mice were also treated with AZT for 7 weeks and developed anemia, leukopenia, thrombocytopenia and myelodysplasia|
| ||BioScience 1991; 41:288-293.||1991|
|Inflammatory Reactions in HIV-1-Infected Persons after Initiation of Highly Active Antiretroviral Therapy.|| ||DeSimone JA et al.
| ||“Inflammatory reactions involving opportunistic infections, AIDS-associated malignant conditions, and other noninfectious diseases (mycobacterium avium complex, acute hepatitis, cirrhosis, herpes zoster, Graves disease, autoimmune thyroiditis, systemic lupus erthematosus, lymphoma and Kaposi sarcoma) have recently been described in patients infected with HIV-1. These conditions often appeared shortly after the introduction of HAART...”|
| ||Ann Int Med. 2000 Sep 19;133(6):447-454.||2000|