Dissident AIDS Database

Co-factorsAZT/PIsAIDS symptomsPCP
Reduction of Maternal-Infant Transmission of Human Immunodeficiency Virus Type 1 With Zidovudine Treatment.
 CONNOR EM, SPERLING RS, GELBER R, et al.
  Two babies born to mothers treated with AZT for 6 months and then treated themselves for an additional month and a half developed Pneumocystis carinii pneumonia. Since the babies were “HIV-negative,” AZT was suspended and they completely recovered, remaining healthy beyond the one-year period of observation.
  NEJM 1994; 331: 1173-1180.1994
Pneumocystis carinii Pneumonia in Infants Who Were Exposed to Human Immunodeficiency Virus But Were not Infected: An Exception to the AIDS Surveillance Case Definition.
 HERESI GP, CACERES E, ATKINSJT, et al.
  Two babies born to mothers treated with AZT for 6 months and then treated themselves for an additional month and a half developed Pneumocystis carinii pneumonia. Since the babies were “HIV-negative,” AZT was suspended and they completely recovered, remaining healthy beyond the one-year period of observation.
  Clin Infect Dis 1997; 25:739-740.1997
Predictors for failure of Pneumocystis carinii pneumonia prophylaxis
 Saah AJ, Hoover DR, Peng Y, Phair JP, Visscher B, Kingsley LA, Schrager LK
  Saah et al. explain their observation that male homosexuals on AZT have a two- to four-fold higher risk of Pneumocystis pneumonia than untreated controls as follows: "Zidovudine was no longer significant after T-helper lymphocyte count was considered, primarily because nonusers had higher cell counts...". The fact that an inhibitor of DNA synthesis designed to kill human cells would reduce lymphocyte counts was not mentioned.
  JAMA 1995; 273: 1197-12021995