Dissident AIDS Database

Co-factorsGlucocorticoidsAIDS symptomsKS
Kaposi’s sarcoma in rheumatoid arthritis.
 Schottstaedt, M.W., Hurd, E.R., Stone,
  KS developed eight months after initiation of prednisone treatment (40 mg per day for three months) in a 58-year-old man with systemic rheumatoid disease. He also had lymphocytopenia (896/µL), reduction of T4 cells (215/µL ), and T4/ T8 ratio of 0.7. This man was HIV-negative as tested by western blot
  M.J. Am J Med 82(5):1021-6, 19871987
Association of Kaposi's sarcoma and prior immunosuppressive therapy: a 5-year material of Kaposi's sarcoma in Norway.
 Klepp O et al
  A retrospective study of 53 cases with a histological diagnosis of Kaposi's sarcoma (KS) reported to The Cancer Registry of Norway during a five year period is presented. Four cases were excluded from the material because further information contradicted the diagnosis of KS. Of the remaining 49 cases, information of treatment received before the development of KS was obtained in 41 (83.7%). Six (14.6%) of the 41 patients developed KS during systemic treatment with corticosteroids, two of the 6 cases also used azathioprine. None of the patients had undergone renal transplantation. One additional patient had received radiotherapy for a malignant lymphoma prior to the development of KS. In a control group of 242 consecutive patients hospitalized because of basal cell carcinoma of the skin, none had used systemic corticosteroid or cytotoxic drugs. Case reports of the 7 patients with KS developing after immunopressive therapy are presented.
  Cancer 42:2626-26301978
KS in renal-transplant recipients : experience at the Catholic University in Rome, 1988-1996
 Lesnoni La Pi et al
  The incidence of Kaposi's sarcoma (KS) in patients transplanted at the Organ Transplant Center of Catholic University in Rome appears to have increased in recent years. To describe the clinical characteristics of KS in a group of transplant recipients. Over 8 years, a total of 302 renal-transplant recipients were followed. When KS was suspected, histology and staging procedures were performed. Ten cases of KS have been diagnosed (8 males, 2 females; age 46.4 +/- 9.4 years); 4 of them were on triple therapy. All the patients were HIV-1 seronegative. The onset of KS occurred 3 months to 4 years after transplantation (21.1 +/- 17.6 months). The disease was limited to the skin in 6 cases and involved internal organs in the remaining 4. Four patients experienced complete remission of the disease following reduction of the immunosuppressive therapy. The high incidence of KS in this population (2.98%), as compared to that reported in other transplant patient groups, suggests that, besides viral infection, genetic predisposition may play a pathogenetic role. However, immunosuppression is the leading factor in transplant patients.
  Dermatology 194(3), 229-33, 19971997
Steroid induced KS in a patient with pre-AIDS
 Schulhafer EP et al
  Kaposi's sarcoma is known to occur in a variety of immunosuppressed patients. The course of the disease varies depending on the underlying risk factors. A male homosexual patient in whom Kaposi's sarcoma developed while he was being treated with prednisone for Henoch-Schonlein purpura is described. The resolution of his lesions once the steroid was discontinued places him in the group of patients whose main risk factor is the steroid itself, rather than the acquired immune deficiency syndrome (AIDS) risk group. A review of the literature on steroid-treated patients in whom Kaposi's sarcoma developed is presented.
  Am J Med 82(2) : 313-317, 19871987
Steroid related development of KS in a homosexual man with Burkitt's lymphoma
 Real FX et al
  The development of Kaposi's sarcoma has been associated with either iatrogenic or disease-related immunodeficiency. This report describes a homosexual man who presented with Burkitt's lymphoma and later had pneumonitis, which was treated with a high dose of corticosteroids. Kaposi's sarcoma subsequently developed, and regressed completely when the chemotherapy and corticosteroid therapy were withdrawn. The evidence from the literature relating corticosteroid therapy to the development of Kaposi's sarcoma is discussed, as well as the possible multifactorial origin of the immunodeficiency in which setting this tumor occurs. The observations in this patient suggest that corticosteroids should be used with extreme caution in patients with acquired immunodeficiency and those at risk for its development.
  Am J Med 1986 : 80 (1) : 119-122, 19861986
KS in an elderly man with Wegener's granulomatosis treated with cyclophosphamide and corticosteroids
 Erban SB et al
  The association of Kaposi's sarcoma with malignant lymphoreticular diseases and immunosuppressive therapy is well documented. This report describes an elderly man who presented with fulminant Wegener's granulomatosis that responded to treatment with cyclophosphamide and corticosteroids. Rapidly progressing cutaneous Kaposi's sarcoma developed ten weeks after the start of immunosuppressive therapy yet regressed on discontinuation of the corticosteroid therapy, despite continuation of cyclophosphamide therapy. To our knowledge, this is the first reported case of Kaposi's sarcoma occurring in association with Wegener's granulomatosis. The literature on Kaposi's sarcoma in immunosuppressed patients is reviewed.
  Arch Intern Med 148 (5) : 1201-1203, 19881988
Kaposi's sarcoma with visceral involvement after intraarticular and epidural injections of corticosteroids.
 Trattner A et al
  Kaposi's sarcoma has been reported in patients receiving immunosuppressive therapy, most of whom are organ transplant recipients. The development of Kaposi's sarcoma after treatment with corticosteroids has been reported in only 38 patients who have not had acquired immunodeficiency syndrome or undergone organ transplantation. Cutaneous Kaposi's sarcoma developed 2 months after intraarticular steroid injections in a man with ulnar nerve entrapment. The lesions regressed spontaneously after 3 months but reappeared with visceral involvement 18 months later, shortly after initiation of a course of epidural steroid injections for treatment of low back pain. The cutaneous lesions and some visceral lesions rapidly regressed after cessation of treatment.
  J Am Acad Dermatol 29 (5 pt 2) : 890-894, 19931993
Dermatomyositis asssociated with the recurrence of transitional cell carcinomas and KS
 Almog Y et al
  A 76-year-old male was admitted to our hospital because of dermatomyositis (DM). Fourteen years earlier a transitional cell carcinoma of the bladder was diagnosed. Following repeated resections of the neoplasm, he was free of the disease for the last two years. Six weeks after starting treatment with steroids and azathioprine for DM, he has developed Kaposi's sarcoma of the skin which subsided upon discontinuation of the immunosuppressive drugs. Four months after the diagnosis of DM, a local recurrence of the bladder carcinoma was found. This patient illustrates the importance of a thorough search for neoplasms or recurrence in elderly patients with dermatomyositis. The case also emphasizes the need for caution in immunosuppressive treatment of autoimmune disorders in such patients. Still, discontinuation of these medications resulted in a significant improvement of the skin neoplasm.
  Clin Exp Rheumatol 9 (3) : 285-288, 19911991
KS associated with the immunosuppression for bullous pemphigoid
 Halpern SM et al
  Kaposi's sarcoma may occur in transplant recipients on immunosuppressive regimens, but is not well recognized in association with treatment for dermatological disease. We report two cases where multifocal Kaposi's sarcoma developed following iatrogenic immunosuppression with prednisolone and azathioprine for bullous pemphigoid. Both patients were HIV negative and, in one case, lesions regressed both clinically and histologically when immunosuppressive therapy was withdrawn.
  Br J Dermatol 137(1) : 140-3, 19971997
Does regressed post-transplantation KS recur following reintroduction of immunosuppression
 Al-Ssulaiman MH
  We report a patient who developed generalized Kaposi's sarcoma (extensive skin and stomach lesions) 24 months after renal transplantation whilst on cyclosporin (CyA) and prednisolone. Kaposi's sarcoma disappeared completely upon withdrawal of CyA. The patient remained with a well-functioning graft and free of Kaposi's sarcoma for 36 months on prednisolone alone. CyA was reintroduced following an episode of acute rejection. Within 8 weeks, Kaposi's sarcoma reappeared on the skin at the same sites as the previously healed lesions. They completely disappeared again upon withdrawal of CyA. Azathioprine was then introduced and Kaposi's sarcoma lesions reappeared 6 months later.
  Am J Nephrol 12 (5) 384-6, 19921992
KS in immunosuppression : possibly the result of a dual viral infection
 Siegal B et al
  Kaposi's sarcoma of the gingiva and skin developed in an HIV-negative renal transplant patient while he was receiving cyclosporine therapy. The Kaposi's sarcoma developed shortly after the patient had an acute infection with cytomegalovirus (CMV). Electron microscopy of the tumor's established cell line showed two types of virus-like particles. CMV DNA was identifiable in the cell line whereas infectious CMV could be isolated only after repeated passages (only after 3 months of culture). The other virus could not be identified, but did not appear to be either HIV or papilloma virus. The patient's tumor regressed after the discontinuation of cyclosporine therapy and the recovery from the acute CMV infection.
  Cancer 65 (3) : 492-8, 19901990
KS as manifestation of immunosuppression of transplant recipients
 Aebischer MC et al
  We report 2 patients, negative for human immunodeficiency virus (HIV) antibodies, who developed generalized Kaposi's sarcoma (KS), one 5 months after renal transplantation while receiving cyclosporin A and prednisone, and the other 24 months after heart transplantation while receiving cyclosporin A, azathioprine and prednisone.
  Dermatology 195 (1) : 91-92, 19971997
Spontaneous manifestation and regression of KS under cyclosporin A therapy
 Pilgrim M
  A case of Kaposi sarcoma is reported in a 40-year-old Turk 3 months after a kidney transplantation under immunosuppression with cyclosporin A and methylprednisolone. After reduction of immunosuppression, there was complete regression of the sarcoma and the kidney transplant functioned correctly.
  Hautarzt 39(6) : 368-70, 19881988