Dissident AIDS Database

Co-factorsHemophilia / factor VIIINon AIDS symptomsForeign proteins
Factor concentrates for treatment of hemophilia: which one to choose?
 Brettler, D.B. & P.H. Levine
  Until recently most commercial preparations of factor VIII contained from 99% to 99.9% foreign, non-factor VIII proteins (albumin, fibrin(ogen), immunoglobulins and immune complexes). The foreign-protein-hemophilia-AIDS hypothesis predicts that long-term transfusion with commercial factor VIII would be immunosuppressive, because of the presence of contaminating proteins. Further, it predicts that pure factor VIII, containing 100- to 1,000-times less foreign protein per functional unit, may not be immunosuppressive.
  Blood 73: 2067-2073, 19891989
Immune status of asymptomatic HIV-infected hemophiliacs: randomised, prospective, two-year comparison of treatment with a high-priority of an intermediate purity factor VIII concentrate
 Mannucci, P.M., A. Gringeri, R. De Biasi, F. Baudo, M. Morfini & N. Ciavarella.
  Until recently most commercial preparations of factor VIII contained from 99% to 99.9% foreign, non-factor VIII proteins (albumin, fibrin(ogen), immunoglobulins and immune complexes). The foreign-protein-hemophilia-AIDS hypothesis predicts that long-term transfusion with commercial factor VIII would be immunosuppressive, because of the presence of contaminating proteins. Further, it predicts that pure factor VIII, containing 100- to 1,000-times less foreign protein per functional unit, may not be immunosuppressive.
  Thromb. Haemost. 67: 310-313, 19921992
Three-year randomised study of high-purity or intermediate-purity factor VIII concentrates in symptom free HIV-seropositive haemophiliacs: effects on immune status
 Seremetis, S.V., L.M. Aledort, G.E. Bergman, R. Bona, G. Bray, D. Brettler, M.E. Eyster, C. Kessler, T.-S. Lau, J. Lusher & E. Rickles
  Until recently most commercial preparations of factor VIII contained from 99% to 99.9% foreign, non-factor VIII proteins (albumin, fibrin(ogen), immunoglobulins and immune complexes). The foreign-protein-hemophilia-AIDS hypothesis predicts that long-term transfusion with commercial factor VIII would be immunosuppressive, because of the presence of contaminating proteins. Further, it predicts that pure factor VIII, containing 100- to 1,000-times less foreign protein per functional unit, may not be immunosuppressive.
  Lancet 342: 700-703, 19931993
Effect of Low and Intermediate-Purity Clotting Factor Therapy on Progression of Human Immunodeficiency Virus Infection in Congenital Clotting Disorders.
 Gjerset, G.E, M.C. Pike, J.W. Mosley, J. Hassett, M.A. Fletcher, E. Donegan, J.W. Parker, R.B. Counts, Y. Zhou, C.K. Kasper, E.A. Operskalski
  Until recently most commercial preparations of factor VIII contained from 99% to 99.9% foreign, non-factor VIII proteins (albumin, fibrin(ogen), immunoglobulins and immune complexes). The foreign-protein-hemophilia-AIDS hypothesis predicts that long-term transfusion with commercial factor VIII would be immunosuppressive, because of the presence of contaminating proteins. Further, it predicts that pure factor VIII, containing 100- to 1,000-times less foreign protein per functional unit, may not be immunosuppressive.
  Blood 84: 1666-1671, 19941994
Particulate material in antihemophiliac factor (AHF) concentrates.
 Eyster, M.E. & M.E. Nau,
  Until recently most commercial preparations of factor VIII contained from 99% to 99.9% foreign, non-factor VIII proteins (albumin, fibrin(ogen), immunoglobulins and immune complexes). The foreign-protein-hemophilia-AIDS hypothesis predicts that long-term transfusion with commercial factor VIII would be immunosuppressive, because of the presence of contaminating proteins. Further, it predicts that pure factor VIII, containing 100- to 1,000-times less foreign protein per functional unit, may not be immunosuppressive.
  Transfusion September-October: 576-581. 1978.1978
Characterization of highly purified factor VIII products.
 Beeser, H.,
  Even the recent "high-purity" factor VIII contains "potentially harming proteins" such as isoagglutinins, fibrin(ogen), split products, immunoglobulins and, when monoclonal antibodies are used for factor VIII preparation, murine proteins in addition to albumin
  Ann. Hematol. 63:126-130. 1991.1991