Dissident AIDS Database

Co-factorsRecreational drugsHeroinNHL
Risk factors for non-Hodgkin's lymphoma according to family history of haematolymphoproliferative malignancies.
 Zhu K, Levine RS, Brann EA, Gu Y, Caplan LS, Hall I, Baum MK.
  Aetiological profiles of non-Hodgkin's lymphoma (NHL) may differ depending upon whether the disease is inheritance-related or sporadic. Because familial risk (a probable surrogate of inheritance-relatedness) of NHL is influenced by haematolymphoproliferative malignancies (HLPM), we evaluated whether non-familial risk factors differ between NHL with and without a family history of HLPM, using the Selected Cancers Study data. Cases were 1511 men aged 31-59 and diagnosed with NHL during 1984-1988. Controls were men without NHL, frequency-matched to cases by age range and cancer registry (n = 1910). These groups were compared: cases with a family history of HLPM and without, and controls without such a family history... Variables only related to NHL with a family history were use of heroin (OR = 15.6, 95% CI : 3.4-70.4)... The higher risks of NHL for homosexual behaviour and heroin use, surrogates of HIV infection, in men with a family history of HLPM imply that genetic susceptibility may be influential on the occurrence of HIV-related NHL.
  Int J Epidemiol. 2001 Aug;30(4):818-24.2001