Dissident AIDS Database

Co-factorsSemen exposureAnal sexLymphocytopenia
Transient antibody to lymphadenopathy-associated virus/human T-lymphotropic virus type III and T-lymphocyte abnormalities in the wife of a man who developed the acquired immunodeficiency syndrome.
 Burger H, Weiser B, Robinson WS, et al.
  The wife of a haemophilia man who, in addition to other sexual acts, practised anal intercourse was found to have a positive antibody test and low numbers of T4 cells. During 10 months of follow-up his wife remained clinically well, discontinued exposure exposure to semen, and then lost the LAV antibody, and regained a normal number of T-helper cells (T4 cells).
  Ann. Int. Med. 1985;103:545-7.1986
 Root-Bernstein R.S; DeWitt S.H.
  "Semen components include sperm, seminal fluid, lymphocytes, and sometimes infectious agents, including HIV, mycoplasmas, and herpes and hepatitis viruses, all of which independently cause immune suppression. Extensive evidence demonstrates sperm (and various viruses) containsmany proteins mimicking the CD4 protein of T-helper cells, while HIV, mycoplasmas, and seminal fluid mimic class II MHC proteins of other lymphocytes. We identify a large number of protein sequences that display such mimicry using computer homology searching, and demonstrate experimentally that sperm antibodies specifically precipitate antibodies against class II MHC mimics such as mycoplasmas, which in turn precipitate antibodies to lymphocyte antigens. These data prove that immunologic exposure to sperm and lymphocytes (as may occur in receptive anal intercourse, needle sharing, or blood transfusions) is theoretically capable of initiating lymphocytotoxic autoimmunity. Such autoimmunity may play a significant role in the pathogenesis of AIDS"
  Genetica 95: 133-56, 19951995