Dissident AIDS Database

Co-factorsStressCortisol mediatedImmuno-deficiency
Effects of hydrocortisone and adrenaline on natural killer cell activity.
 Nomoto Y, Karasawa S, Uehara K.
  "We have studied the effects of hydrocortisone and adrenaline on natural killer (NK) cell activity and on the distribution of circulating lymphocyte subpopulations in 30 patients undergoing elective partial laminectomy under general anaesthesia. The patients were allocated to receive adrenaline (group 1, n = 11), hydrocortisone and adrenaline (group 2, n = 11) or neither hydrocortisone nor adrenaline (group 3, n = 8)... compared with groups 1 and 3, group 2 showed a significantly reduced CD4/CD8 cell ratio during operation. Therefore, these results suggest that even in cases of such severe stress that the immune response was depressed by increased serum cortisol concentrations..."
  Br J Anaesth 1994 Sep;73(3):318-211994