|HIV drugs||AZT/PIs||Ineffectiveness||Giving up|
|AIDS toll on the rise.|| ||Rose S.
| ||“Clinicians are now realizing that the existing therapies are no longer long-term therapies, they start to give out sometimes within two years.”|
| ||Provincetown Banner. 2000 Sep 21.||2000|
|In U.S. cities, successful HIV treatment rare|| ||No author
| ||“One of the first studies to look at the success of HIV treatment in inner-city patients from the time of diagnosis reveals a dire situation, a doctor working in Atlanta, Georgia, said here on Tuesday at the 8th Conference on Retroviruses and Opportunistic Infections. His study found that only 1 in 10 patients newly diagnosed with HIV achieved a reduction in virus in blood to ''undetectable'' levels--a major goal of treatment...One year after being diagnosed, 24 patients (18%) had died, del Rio reported. Of the 103 eligible to attend an outpatient clinic, the majority discontinued treatment after a few months. Only 55 patients (53%) ever went to the outpatient clinic and 40% of these dropped out within 1 year. Of the 55 patients seen at the outpatient clinic, 30 were prescribed antiretroviral therapy. One year from diagnosis, only 23 were still on therapy and 12 (of the original 135 patients) had undetectable levels of virus in their blood. ”|
| ||Reuters. 2001 Feb 7.||2001|
|The case for more cautious, pateint-focused antiretroviral therapy.|| ||Henry K.
| ||“current potent regimens do not completely inhibit HIV replication in most patients...resistance develops during ongoing HIV replication in the presence of anti-HIV drugs...in most patients...Although it may seeem reasonable to believe that use of potent therapy could delay or prevent the evolution of more virulent strains of the virus, few data support that argument...cure with current potent therapy may be possible after 10 years of therapy, 60 to 115 years of therapy, or never [depending on the research cited]...it is safe to conclude that a cure is extremely unlikely with the current approach to treatment......The fastest-growing treatment category in my clinic [Regions Hospital, Minnesota] is no treatment or delayed treatment.”|
| ||Ann Int Med. 2000 Feb 15;132(4):306-311.||2000|