Dissident AIDS Database

HIV drugsAZT/PIsIneffectivenessLack of specificity
Zidovudine for the treatment of HIV-negative patients with psoriasis: a pilot study
 Townsend BL, Cohen PR, Duvic M.
  AZT was used in a study of psoriasis sufferers. In four out of 12 sufferers most of the psoriasis was cleared up. The theory to support the finding is that since AZT stops cell replication it slows skin proliferation, which is normally rapid. In other words AZT was prescribed to psoriasis patients to kill growing cells by inhibiting cellular DNA synthesis while also prescribed to HIV-positives and AIDS patients as a specific inhibitor of HIV DNA synthesis targeting HIV-infected cells and inhibiting viral replication.
  J Am Acad Dermatol 1995 Jun;32(6):994-91995
Treatment of adult T-cell leukemia-lymphoma with a combination of interferon alfa and zidovudine.
 Gill PS, Harrington WJ, Kaplan MH, Ribeiro RC, Bennett JM, Liebmann HA, Bernstein-Singer M, Espina BM, Cabral L, Allen S, et al.
  This study reports the use of AZT with interferon-alpha in 19 patients with adult T-cell leukemia-lymphoma. They reported five remissions and 11 ‘major responses’. The logic goes that since AZT kills cells, particularly rapidly growing ones such as cancerous cells, then it will be effective. In other words AZT was prescribed to cancer patients to kill growing cells by inhibiting cellular DNA synthesis while also prescribed to HIV-positives and AIDS patients as a specific inhibitor of HIV DNA synthesis targeting HIV-infected cells and inhibiting viral replication.
  NEJM 1995; 332: 1744-1748.1995