Dissident AIDS Database

HIV drugsAZT/PIsSide effectsDiabete
The Mechanism of Insulin Resistance Caused by HIV Protease Inhibitor Therapy.
 Murata H, Hruz PW, Mueckler M.
  “Retroviral protease inhibitors used as therapy for HIV-1 infection have been causally associated ... in some cases, overt type 2 diabetes...We demonstrate that the HIV protease inhibitor, indinavir, dramatically inhibits insulin-stimulated glucose uptake in 3T3-L1 adipocytes in a dose-dependent manner...Similar effects on glucose transport were observed for other HIV protease inhibitors. We conclude that HIV protease inhibitors as a class are capable of selectively inhibiting the transport function of Glut4 and that this effect may be responsible for a major iatrogenic complication frequently observed in HIV patients [insulin resistance].”
  JBC. 2000 May 9.2000