Dissident AIDS Database

HIV drugsAZT/PIsSide effectsHyperglycemia
Effects of Protease Inhibitors on Hyperglycemia, Hyperlipidemia, and Lipodystrophy.
 Tsiodras S et al.
  “Our study reports an independent association between PI [protease inhibitors] use and ... hyperglycemia, ... on the basis of a 5-year cohort study that encompassed the pre-PI and post-PI therapeutic eras. Although these metabolic changes were occasionally observed in patients not exposed to PIs, they were much more frequent after initiation of PI therapy.”
  Arch Intern Med. 2000 Jul 10;160(13):2050-62000
Protease inhibitor-associated hyperglycaemia.
 Dube MP et al.
  “Protease inhibitors can be associated with a non-ketosis-prone hyperglycaemia that occurs 1-7 months after starting treatment”
  Lancet. 1997 Sep;350:713-4.1997
Lactic acidosis and hypoglycaemia in three neonates exposed to HAART in utero.
 Foster CJ et al.
  “ three cases of unexplained neonatal lactic acidosis and hypoglycemia, either alone or in combination, in non-HIV-infected infants exposed perinatally to Retrovir (zidovudine, AZT), Epivir (lamivudine, 3TC) and Viramune (nevirapine). At birth, two of the three infants had severe acidosis, with a pH less than 7.1, and the third infant, as well as one of the 2 infants with lactic acidosis, had severe and persistent hypoglycemia.”
  7th Annual Conference of the British HIV Association. April 2001. Oral Abstract 020.. 2001 April;Abstract 20.2001