Dissident AIDS Database

HIV drugsBactrimSide effectsGeneral
Manufacturer's notice
 Roche
  "Chronic: Use of Bactrim at high doses and/or for extended periods of time may cause bone marrow depression manifested as megaloblastic anemia"
  http://www.rocheusa.com/products/bactrim/pi.html#OVERDOSAGE1
Oral therapy for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome: A controlled trial of trimethoprim-sulfamethoxazole versus trimethoprim-dapsone.
 Medina I, Mills J, Leoung G, et al.
  57% of patients with advanced HIV disease receiving TMP-SMZ and 30% of those receiving trimethoprim-dapsone (TMP-DAP) developed major Toxicity requiring a change of therapy to pentamidine.
  N Engl J Med 1990;323:776-782.1990
Trimethoprim-sulfamethoxazole or pentamidine for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome: A prospective randomized trial.
 Wharton JM, Coleman DL, Wofsy CB, et al.
  Trimethoprim-sulfamethoxazole (TMP-SMZ) has been associated with adverse effects in up to 100% of patients with AIDS.
  Ann Intern Med 1986;105:37-44.1986
Pneumocystis carinii pneumonia: A comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies.
 Kovacs JA, Hiemenz JW, Macher AM, et al
  Trimethoprim-sulfamethoxazole (TMP-SMZ) has been associated with adverse effects in up to 100% of patients with AIDS.
  Ann Intern Med 1984;100:663-671.1984
Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome.
 Gordin FM, Simon GL, Wofsy CB, et al.
  Trimethoprim-sulfamethoxazole (TMP-SMZ) has been associated with adverse effects in up to 100% of patients with AIDS.
  Ann Intern Med 1984;100:495-499.1984
Rapid disease progression in human immunodeficiency virus type 1-infected individuals with adverse reactions to trimethoprim-sulfamethoxazole prophylaxis.
 Veenstra J et al.
  “The present study reveals a relationship between the occurrence of adverse reactions to TMP-SMZ and the course of HIV infection. ”
  Clin Infect Dis. 1997 May;24(5):936-41.1997