Dissident AIDS Database

HIV drugsInterleukin-2Side effectsHyperlactatemia
Chronic hyperlactatemia in HIV-infected patients taking antiretroviral therapy.
 John M et al.
  “In 516 patient-years of observation, 2 patients experienced severe fulminant lactic acidosis (lactate >5 mmol/l) and hepatic steatosis attributable to nucleoside analogue reverse transcriptase inhibitors (NRTI). A further 5 patients with lesser elevations of lactate (2.8-4.1 mmol/l) but with symptoms of nausea or abdominal discomfort and evidence of hepatic steatosis had NRTI therapy revised, with relief of symptoms and a fall in lactate levels. Most remaining patients on highly active antiretroviral therapy (HAART) had mild, chronic, asymptomatic hyperlactatemia”
  AIDS. 2001 Apr 13;15(6):717-723.2001