Dissident AIDS Database

HIV drugsPolypharmacySide effectsChildren
Older Children and Adolescents Living with Perinatally Acquired Human Immunodeficiency Virus Infection.
 Grubman S, Gross E, Lerner-Weiss N, Hernandez M, McSherry GD, Hoyt LG, Boland M, Oleske JM.
  The polypharmacy of adult HIV-positives even extends to children. The treatments prescribed to an American group of 20 boys and 22 girls serve as an example. These children were originally diagnosed as HIV-positive only at 7 years of age, but were HIV-positive from birth due to perinatally acquired HIV. At the time of HIV diagnosis, 5 of 42 (12%) were also diagnosed with some AIDS-defining diseases. Yet all but 2 of the children were treated with anti-HIV/AIDS drugs. Most of the children are receiving multiple chronic medications, with 90.5% (38 of 42) receiving antiretroviral therapy, 78.6% (33 of 42) receiving PCP prophylaxis, 33.3% (14 of 42) receiving fungal prophylaxis, and 23.8% (10 of 42) receiving herpesvirus prophylaxis. Among the children receiving antiretroviral therapy, 78.9% (30 of 38) are receiving zidovudine [AZT]. Other medications frequently prescribed include meter dose inhalers for reactive airway disease in 33.3% (14 of 42) of patients and nutritional supplements for failure to thrive and wasting syndrome in 52.4% (22 of 42) of patients. Only 2 of the 42 children in the cohort are not receiving any medications, with 4 receiving one medication, 14 receiving two, 10 receiving between 3 and 5, and 12 receiving between 6 and 12 different medications daily. Sixty-two percent (26 of 42) of the children receive monthly intravenous infusions of immunoglobulin.
  Pediatrics 1995; 95: 657-663.1995