Dissident AIDS Database

HIV drugsPolypharmacySide effectsOverdosage
The drug-Aids hypothesis
 Duesberg Peter, Rasnick David
  The licensing study conducted in 1986 by the National Cancer Institute (NCI) and Burroughs Wellcome had erroneously underestimated the toxicity of AZT for human cells a 1000-fold! Although at least 7 independent studies have since pointed out this 1000-fold error, the recommended prescription dose has only been reduced 3-fold, from 1.5 g of AZT per day in 1987 to 0.5 g now (Furman PA, Fyfe JA, St Clair M, Weinhold K, Rideout JL, Freeman GA, Nusinoff-Lehrman S, Bolognesi DP, Broder S, Mitsuya H, Barry DW, Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase, PNAS 1986; 83: 8333-8337. Mansuri MM, Hitchcock MJM, Buroker RA, Bregman CL, Ghazzouli I, Desiderio JV, Starrett JE, Sterzycki RZ, Martin JC, Comparison of in vitro biological properties and mouse toxicities of three thymidine analogs active against human immunodeficiency virus, Antimicrobial Agents and Chemotherapy 1990; 34: 637-641. Lemaître M, Guetard D, Henin Y, Montagnier L, Zerial A, Protective activity of tetracycline analogs against the cytopathic effect of the human immunodeficiency viruses in CEM cells, Res Virol 1990; 141: 5-16. Avramis VI, Markson W, Jackson RL, Gomperts E, Biochemical pharmacology of zidovudine in human T-lymphoblastoid cells, AIDS 1989; 3: 417-422. Sommadossi J-P, Zhu Z, Carlisie R, Xie M-Y, Weidner DA, El Kouni MH, Novel pharmacological approaches to the treatment of AIDS and potential use of uridine phosphorylase inhibitors, Advances in Chemotherapy of AIDS, R. B. Diasio and J.-P. Sommadossi (eds.) Pergamon Press Inc., New York, 1990; 63-73. Inoue T, Tsushita K, Itoh T, Ogura M, Hotta T, Saneyoshi M, Yoshida S, Saitoh H, Tomoda Y, Nagai Y, In vitro bone marrow toxicity of nucleoside analog against human immunodeficiency virus, Antimicrob Agents Chemother 1989; 33: 576-579. Gogu SR, Beckman BS, Agrawal KC, Anti-HIV drugs: Comparative toxicities in murine fetal liver and bone marrow erythroid progenitor cells, Life Sci 1989; 45: iii-vii).
  Continuum Feb./March 19971997