Dissident AIDS Database

NIAID paper : HIV causes AIDSDeveloped countriesHemophilia / factor VIIIDarby study
No title
 Johnston R, Irwin M, Crowe D, Philpott P
  (Darby SC, Ewart DW, Giangrande PL, Dolin PJ, Spooner RJ, Rizza CR, Mortality before and after HIV infection in the complete UK population of haemophiliacs. UK Haemophilia Centre Directors' Organisation, Nature 1995 Sep 7;377(6544):79-82) A team researchers headed by Sarah Darby recorded annual mortality rates every two years for 4,043 British hemophiliacs who "received potentially [HIV] infected treatments" between the years 1977 and 1992. Their data revealed that between the years 1977 and 1984, annual mortality was stable and low, at about 4 deaths per 1,000 for patients with mild-to-severe hemophilia, and twice as high for patients with severe hemophilia, at about 8 per 1,000. HIV testing was introduced in 1985, and administered to most of Darby's subjects by the end of that year. When annual mortality was next calculated, at the end of 1986, it was found to have tripled to about 24 per 1,000 for severe hemophiliacs, and to have increased by about five times to 20 per 1,000 for mild-to-severe hemophiliacs who had tested HIV-positive. No increased mortality was observed for those who tested HIV-negative. Both trends continued through the course of the study. "During 1985-'92, there were 403 deaths in HIV seropositive patients, whereas 60 would have been predicted from rates in seronegatives", suggesting that all of these 343 excess deaths "were due to HIV infections" and "that 85% of the deaths in the seropositives were due to HIV infection." => Problem 1) whereas about half of Darby's 2,037 severe hemophiliacs were already HIV-positive by 1985, there was no detectable mortality increase prior to the introduction of HIV testing. Problem 2) un-purified Factor VIII injections can ultimately result in dose-dependant immune suppression even in HIV-negative hemophiliacs. Since HIV is a rare contaminant of Factor VIII, it takes many injections to finally become positive for it. Thux, HIV + hemophiliacs are usually more immuno-suppressed because they have acquired more un-purified Factor VIII (meaning that they have more severe hemophilia or have had haemophilia for a longer time). Problem 3) Darby obtained her cause of death information by examining death certificates. According to a press report from Australia ("Doctors Admit Helping in AIDS Deaths", Sydney Morning Herald, November 17, 1995 : among 1,300 deaths of HIV-positive Australians over a two-year period, 500 were medically-assisted suicides), suicides in HIV-positive hemophiliacs are not necessarily listed as such in the death certificates but may only be recorded as "AIDS related." Problem 4) Darby lists only 235 HIV-positive deaths as resulting from AIDS (44 cases of death by "AIDS conditions" are also mentionned for diseases classically related to haemophilia) : thus the deaths attributed to "AIDS, HIV, etc." make up 58% (235/403) of the total, not 85% (343/403)! Further, the death rate due to non 'HIV causes', is three times what they it should have been, based on the death rate in the HIV- population. Moreover, it is not possible to say how many of the 235 haemophiliacs died from "mild and moderate diseases" (which following the 1985 CDC AIDS definition signified AIDS) or from AIDS defining conditions according to the 1987 CDC definition (according to which a patient could have been certified as dying from AIDS without a definite disease diagnosis). Problem 5) According to the CDC : "It is possible that antibody to LAV is acquired passively from immunoglobulins found in factor VIII concentrates..... Likewise, it is possible that seropositivity is caused not by infectious virus but by immunisation with noninfectious LAV or LAV proteins derived from virus disrupted during the processing of plasma into factor VIII concentrate". Problem 6) The authors acknowledge that "treatment, by prophylaxis against Pneumocystis carinii pneumonia or with zidovudine [AZT] has been widespread" in HIV-positive hemophiliacs
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