Dissident AIDS Database

TreatmentHiv drugs beneficial effectsAZT/PIsCandidiasis
In vitro and in vivo anticandidiasisl activity of human immunodeficiency virus protease inhibitors
 Cassone A, De Bernardis F, Torosantucci A, Tacconelli E, Tumbarello M, Cauda R
  "Highly active antiretroviral therapy that includes human immunodeficiency virus (HIV) aspartyl protease inhibitors (PIs) causes a decline in the incidence of some opportunistic infections in AIDS, and this decline is currently attributed to the restoration of specific immunity. The effect of two PIs (indinavir and ritonavir) on the enzymatic activity of a secretory aspartyl protease (Sap) of candidiasis albicans (a major agent of mucosal disease in HIV-infected subjects) and on growth and experimental pathogenicity of this fungus was evaluated. Both PIs strongly (>/=90%) and dose dependently (0.1-10 microM) inhibited Sap activity and production. They also significantly reduced candidiasis growth ... with an efficacy comparable to that of fluconazole. Thus, besides the expected immunorestoration, patients receiving PI therapy may benefit from a direct anticandidiasisl activity of these drugs."
  J Infect Dis 1999 Aug;180(2):448-531999