Dissident AIDS Database

TreatmentHiv drugs beneficial effectsAZT/PIsOxidative stress
Improved Antioxidant Status Among HIV-Infected Injecting Drug Users on Potent Antiretroviral Therapy
 Peace, Rod Knoll
  "Low serum antioxidant levels in HIV-infected people have been attributed to altered metabolism associated with excess oxidative stress. We conducted a study to examine serum antioxidant levels in 175 HIV-positive and 210 HIV-negative injecting drug users. At the time of data collection, 30 of theHIV-positive IDUs were receiving antiretroviral therapies (ART) including a protease inhibitor (PI), 43 ARTwithout a PI, 22 monotherapies, and 80 not on any ART... Serum levels of these three antioxidants were significantly higher in the PI group than in the other three ART groups combined (p = .0008, 0.02, and 0.02, respectively). These data provide indirect evidence of the effectiveness of PIs in lowering oxidative stress levels in HIV-positive IDUs."
  Journal of Aids 2000;23:321-3262000